Molecular pathways for lymphangiogenesis and their role in human disease.
Identifieur interne : 007189 ( Main/Exploration ); précédent : 007188; suivant : 007190Molecular pathways for lymphangiogenesis and their role in human disease.
Auteurs : Steven A. Stacker [Australie] ; Rae H. Farnsworth ; Tara Karnezis ; Ramin Shayan ; Darrin P. Smith ; Karri Paavonen ; Natalia Davydova ; Carol Caesar ; Rachael Inder ; Megan E. Baldwin ; Bradley K. Mccoll ; Sally Roufail ; Richard A. Williams ; Richard A. Hughes ; Kari Alitalo [Finlande] ; Marc G. AchenSource :
- Novartis Foundation symposium [ 1528-2511 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Lymphangiogenèse, Transduction du signal.
- métabolisme : Facteurs de croissance endothéliale vasculaire, Tumeurs.
- physiologie : Lymphangiogenèse, Transduction du signal.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Vascular Endothelial Growth Factors.
- genetics : Lymphangiogenesis, Signal Transduction.
- metabolism : Neoplasms.
- physiology : Lymphangiogenesis, Signal Transduction.
- Humans.
Abstract
The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.
PubMed: 17534064
Affiliations:
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Stacker</name><affiliation wicri:level="1"><nlm:affiliation>Angiogenesis Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, 3050, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Angiogenesis Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, 3050, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Farnsworth, Rae H" sort="Farnsworth, Rae H" uniqKey="Farnsworth R" first="Rae H" last="Farnsworth">Rae H. Farnsworth</name></author><author><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name></author><author><name sortKey="Shayan, Ramin" sort="Shayan, Ramin" uniqKey="Shayan R" first="Ramin" last="Shayan">Ramin Shayan</name></author><author><name sortKey="Smith, Darrin P" sort="Smith, Darrin P" uniqKey="Smith D" first="Darrin P" last="Smith">Darrin P. Smith</name></author><author><name sortKey="Paavonen, Karri" sort="Paavonen, Karri" uniqKey="Paavonen K" first="Karri" last="Paavonen">Karri Paavonen</name></author><author><name sortKey="Davydova, Natalia" sort="Davydova, Natalia" uniqKey="Davydova N" first="Natalia" last="Davydova">Natalia Davydova</name></author><author><name sortKey="Caesar, Carol" sort="Caesar, Carol" uniqKey="Caesar C" first="Carol" last="Caesar">Carol Caesar</name></author><author><name sortKey="Inder, Rachael" sort="Inder, Rachael" uniqKey="Inder R" first="Rachael" last="Inder">Rachael Inder</name></author><author><name sortKey="Baldwin, Megan E" sort="Baldwin, Megan E" uniqKey="Baldwin M" first="Megan E" last="Baldwin">Megan E. Baldwin</name></author><author><name sortKey="Mccoll, Bradley K" sort="Mccoll, Bradley K" uniqKey="Mccoll B" first="Bradley K" last="Mccoll">Bradley K. 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Achen</name></author></analytic><series><title level="j">Novartis Foundation symposium</title><idno type="ISSN">1528-2511</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Lymphangiogenesis (genetics)</term><term>Lymphangiogenesis (physiology)</term><term>Neoplasms (metabolism)</term><term>Signal Transduction (genetics)</term><term>Signal Transduction (physiology)</term><term>Vascular Endothelial Growth Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de croissance endothéliale vasculaire (métabolisme)</term><term>Humains</term><term>Lymphangiogenèse (génétique)</term><term>Lymphangiogenèse (physiologie)</term><term>Transduction du signal (génétique)</term><term>Transduction du signal (physiologie)</term><term>Tumeurs (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factors</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lymphangiogenèse</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de croissance endothéliale vasculaire</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G" last="Achen">Marc G. Achen</name><name sortKey="Baldwin, Megan E" sort="Baldwin, Megan E" uniqKey="Baldwin M" first="Megan E" last="Baldwin">Megan E. Baldwin</name><name sortKey="Caesar, Carol" sort="Caesar, Carol" uniqKey="Caesar C" first="Carol" last="Caesar">Carol Caesar</name><name sortKey="Davydova, Natalia" sort="Davydova, Natalia" uniqKey="Davydova N" first="Natalia" last="Davydova">Natalia Davydova</name><name sortKey="Farnsworth, Rae H" sort="Farnsworth, Rae H" uniqKey="Farnsworth R" first="Rae H" last="Farnsworth">Rae H. Farnsworth</name><name sortKey="Hughes, Richard A" sort="Hughes, Richard A" uniqKey="Hughes R" first="Richard A" last="Hughes">Richard A. Hughes</name><name sortKey="Inder, Rachael" sort="Inder, Rachael" uniqKey="Inder R" first="Rachael" last="Inder">Rachael Inder</name><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name><name sortKey="Mccoll, Bradley K" sort="Mccoll, Bradley K" uniqKey="Mccoll B" first="Bradley K" last="Mccoll">Bradley K. Mccoll</name><name sortKey="Paavonen, Karri" sort="Paavonen, Karri" uniqKey="Paavonen K" first="Karri" last="Paavonen">Karri Paavonen</name><name sortKey="Roufail, Sally" sort="Roufail, Sally" uniqKey="Roufail S" first="Sally" last="Roufail">Sally Roufail</name><name sortKey="Shayan, Ramin" sort="Shayan, Ramin" uniqKey="Shayan R" first="Ramin" last="Shayan">Ramin Shayan</name><name sortKey="Smith, Darrin P" sort="Smith, Darrin P" uniqKey="Smith D" first="Darrin P" last="Smith">Darrin P. Smith</name><name sortKey="Williams, Richard A" sort="Williams, Richard A" uniqKey="Williams R" first="Richard A" last="Williams">Richard A. Williams</name></noCountry><country name="Australie"><noRegion><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A" last="Stacker">Steven A. Stacker</name></noRegion></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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